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I am working on a list, and I am wondering if anyone knows of any natural plants that anyone can find anywhere. Once this list is done, anyone that reads it should be able to find themselves a natural Anti-Depressant or even just mood elevator.

While working on this, I accidentally came across the phrase Oilhuasca. I make my own essential oils from Cinnamon and Lemon Peel and Peppermint leaf and all that, and I have been wanting to do some “Pihkal” and “Tihkal” type smell research. So when I was researching plants that activate these receptors, and found the phrase “Oilhuasca” a whole new landscape opened up in front of me. I AM NOT CLAIMING TO BE AN OILAHUASCA EXPERT, DO YOUR OWN RESEARCH AFTER READING.

I recently found out that Bitter Orange extract is like Norepinephrine, which really made me second think for a second. I knew Ephedra contained Ephedra which is used to make meth, but that never interested me. And I also knew that MDA/MDMA could be make from Black Pepper or Sassafras, but I don't want to be an ecstasy cook.

And I have known about Entheogens, everything from San Pedro, to Datura to Amanita or Marijuana and Betel. I have read about almost everything and have tried a few things. But these are always classified as “Psychedelic” or “Stimulant” or “Sedative”. And most of the stuff people are looking for are “Opiate Replacements” or “Marijuana Replacements” and I am not really interested in Opium, or replacing Marijuana.

So, we know of plants that contain DMT, and LSA and Mescaline, but we don't really pay attention to the plants that act on those SAME receptors, just in a lighter way. So, why not do that now?

I can hardly find anything about this stuff online, but some people have posted some stuff and here is what I can find.

Graviola- 5-HT1a Agonist Black Cohosh- 5-HT1A, 5-HT1D & 5-HT7 Binding C. Foetida L.- 5-HT1A Agonist Yokukansan- 5-HT1A Agonist

DMT hits ALL of these, and can be found in tons of plants.

If anyone can find something that binds/agonizes the 5-HT1B receptor, please post it. All I can find that is not a prescription is TFMPP, but that is not from a plant. There are also “Triptans” but they are also not natural.

I can't find anything that goes to the 5-HT1D receptor except black Cohosh.

St. John's Wort should be on here, I just can't find out where. And 5-HTP, L-Theanine and L-Tryprophan can help also, but I am not sure if they are specific in their action. Kanna should be on here, but I don't know exactly where. And maybe Rhodiola rosea, Albizia lebbeck & Albizia julibrissin.

I read some where that these are 5-HT1 Receptor Agonists: Turmeric, Ginger, Ginko Bilboa, Lemon Essential Oil, Rauwolfia, Valerian, Yohimbe

(also from what I have read) Elmicin & Myristicin (in Nutmeg)- 5-HT2A Agonist Estragole (in Sweet Basil)- 5-HT2A Agonist Safrole (in Sassafras)- 5-HT2A Agonist

Those 4 oils are the main oils used in Oilahuasca, please name more if you know them. They say they can be taken by swallowing, huffing or rubbing it on your skin.

Some people report Black Pepper being of use by adding Peperidine to the body, some claim black pepper made things weaker. Just thought I would add that here. Making Pepper tea with water and filtering out the solids can help keep the good stuff in and keep the bad stuff out they say. And Synephrine might do something with the pepper. Also, L-Lysine can be used instead of pepper.

These next oils are the oils you need to activate them. Cinnamon Bark- CYP2A6 & CYP2E1 Inhibitor (It will deplete your liver's Glutithione) Taken 1 Hour before Allybenzene, Clove Leaf- CYP2C9, CYP3A4, CYP1A1 & CYP1B1 Inhibitor German Chamomile- CYP1A2 Inhibitor (Caffeine may also do this)

Also GoldenSseal & Echinacea purpurea very effectively do the same thing. And people have reported using Vitamin B9 or Almond extract or Star Anise Extract and Tangerine Peels or Extract.

And from what I am finding now, Black seed oil, 50% EGCG, Valerian root oil, Pomegranate, Vitamin B9, 40% Ellagic extract, Rooibos 20% Gallic acid extract, Rutin, B3 & Kudzu are best here. THC is also said to have an effect here.

I have read something about DMSO being used with these, not exactly sure on this though.

This supposedly only leaves a few enzymes to break things down, rendering these things orally active. They may not work for everyone, and dosage is unsure at this point. But people have reported better results with Phenethylamine (Some people say you NEED to take it with your Allylbenzene, or at least some kind of 'amine' like Tryptamine) and Phenelalanine. As well as Coffee and Cayenne Pepper. Milk may also do something, it contains a few things like Tryptophan and Choline.

The 4 Oils listed are “AllylBenzenes”, here is a larger list, but I am not sure if anyone has ever tried to Oilahuasca these yet, and I do not know if it is safe, so I am not suggesting anyone try these, they are just here for the sake of discussing them so people in the future can be safe.

Anethole, Apiol, Asarone, Carpacin, Chavibetol, Chavicol, Dillapiole, Eugenol, Isoeugenol, Isosafrole, Methyl Eugenol, Methyl Isoeugenol,

And since Cinnamon is a Phenylpropanoid, and Phenylpropanoids are made from Phenelalamine, and people who took Phenelalamine claim to get better results. I decided to post a list of Phenylpropanoids also.

Caffeyl Alcohol, Cinnamaldehyde, Cinnamyl alcohol, alpha-Cyno-4-hydroxycinnamic acid, Ethyl Cinnamate, Lignin, 2,4-Methlenedioxypropiophenone, Neoflavonoids, Nordihydroguaiaretic acid, Phenylpropanoic acid, Phloretic acid, Rhododendrin & Suberin.

Here are the things that you need to make sure the Oil works.

Star Anise Extract or B9 for CYP2C9 Induction

Most important things: CYP2C9 Induction Alcohol Dehydrogenase Induction Aldehyde Dehydrogenase Inhibition Piperidine and or Dimethylamine Supplementation Methyl from foods Exercise or compounds that produce effects like exercise

Less important, but still factors: SSAO Inhibition (Caffeine, Phenethylamine, Phenelalamine, Tryptamine) MAO-A Induction MAO-B Induction NDMA Antagonism Prolactin Inhibition

Here are some Piperadines (Pepper Replacement) Thioridazine, Haloperidol, Mesoridazine, Raloxifene, Loperamide, Risperidone & Paroxetine

Peppermint oil has also been talked about as a possible base instead of the Allylbenzenes.

And there is an Oilhuasca diet you are supposed to keep up for a day or so before the Oilahusca, because some foods naturally counteract these effects you are looking for. If you take lots of Vitamins and stuff too, some of those could get in the way. If you look up “Oilahuasca Diet” you can find it.

No one seems to have mentioned this, but MAOIs could help in this also. But do not eat Chocolate, Cheese or Alcohol if you take MAOIs.

Hungarian Parsley Seed is a better source of Myristicin, just found that out. And the effects of it when activated properly are said to be like Mescaline and MDMA together. The P450 Enzymes CYP1A2 & CYP3A4 are what break this down and need to be inhibited. CYP2D6 could also play a big role.

Elmicin is something you either needs Chromotography type knowledge to get, or you have to buy it in small quantities. When activated properly it is like Mescaline, when activated wrong it is like Melatonin (sleepy). CYP1A1, CYP1B1, CYP1A2, CYP2A6, CYP2C9, CYP2A6, CYP2C9 & CYP2E1 are what are needed to be inhibited to activate this. CYP2D6 could also play an important role.

Safrole is like MDMA when activated properly and like Melatonin when not. CYP2A6, CYP2C9, and CYP2E1 are most important for this. CYP2D6 could also be important.

Methyl Chavicol when activated properly is like a light speedy LSD, when activated wrong it is said to be almost like Marijuana. CYP1A2 and CYP2A6 inhibit it, and CYP2D6 could also be important.

If the CYP2D6 Enzyme is inhibited with all the others, these are possibly visually hallucinogenic Oilahuascas. And the Methyl Chavicol doesn't build a tolerance (the others do) it actually gets stronger for you every time you use it, or you can use less.

Dill seed extract also is said to be able to be used. As one of the main things, like in place of the Chavicol.

And apparently you can turn the main ingredients into 3 different forms, depending what you take: Dimethylamine, Piperidine and the Pyrrolidine derivatives Piperidine is said to be the strongest and is made by having Pepper or a Pepper replacement in your system.

And Apparently Elami oil can be activated by Valerian Root of Chinese origin, Coffee, Almond Extract & Glycerin (the stuff E-Cig liquid is made of), and nothing else. And it is like Mescaline. Someone told that guy that he didn't even need the Valerian root, and if he had added Vanilla or Cumin oil to his coffee, it could have been even stronger. So basically if someone were to drink a Nutmeg, Vanilla, Almond Coffee… They could trip and not even expect it.

Ok, so I just read coffee inhibits Xanthine Oxidase, which is key is some people while other people can get effects just fine without the inhibitor there. But to be safe, if you want to ever try any of these, take a small amount of caffeine or drink a cup of coffee and see if it helps. (I will be trying all this stuff as soon as I can grow or order all the stuff for it)

Someone else said that Valerian Root oil might actually be the key, because it Inhibits CYP2C9. Lol. So, I guess the key is just to try as many Inhibitors as possible, and try not to take to much of the base oil so that you don't trip too hard.

Valerian Root, B9, Anise seed are all interchangeable or to be used together or replaced with: DHEA (dehydroepiandrosterone) Eugenol (inhibits/induces CYP2C9) Ginkgo biloba (inhibits/induces CYP2C9) Licorice (inhibits/induces CYP2C9) Milk Thistle Resveratrol (inhibits CYP2C9) Saint John’s Wort (inhibits/induces CYP2C9) Turmeric (inhibits/induces CYP2C9)

Pepper tea, with the solids taken out, seems to be the best thing for creating the base base.

L-Lysine is said to really help the pepper.

Vanilla and Cinnamon seem to be interchangable. They are both Aldehydes.

German Chamomile does the best at blocking CYP1A2, but you can use Cayenne Peppers or Tangeretin.

CYP2A6 can be inhibited by: Almond Extract, Anise oil, Benzaldehyde, Cinnamaldehyde, Lemon oil, Lime oil, Orange oil, Limonene, Tangerine oil, Lemongrass oil, Nicotine

CYP2D6 Inhibition could mean the difference between Psychedelic effects and no effects. Here are the things that inhibit it: CBD (Cannabidiol from Cannabis), Echinacea Purpurea, Pomegranate, Pummelo, Calamus oil, Kava, Black Cohosh

CYP3A4 is important to inhibit, which can be done with: Catechin, Clove oil, Dill seed oil, Ginger, Goldenseal, Pomegranate, Cinnamon & Kava.

Kudzu seems to help protect it after it is formed. This can be replaced by Gallic Acid, Soy Isoflavones, Glycerin, Caffeine or Benzaldehydge.

And if anyone were to try these things with Mescaline or MDMA or DMT, they would probably get some awesome effects. I am not sure if anyone has tried it yet, but there may be other versions of Ayahuasca to make, where you take DMT orally and have it made into something else by inhibiting certain enzymes.

Cayenne Peppers promote Endophines and Adrenaline, so they also put things in the body that are helpful.

Just to add, It would probably also be good to take Phenethylamine, Phenelalamine, Tryptamine or even just Choline or Tryptophan or 5-HTP if that is all you can get.

From what I read earlier, any NMDA antagonist would be beneficial, but not crucial in the mix. This makes sense to me, because NMDA antagonists are things like, Ecstasy or Cough Medicine (Delsym) or MXE. So it would make sense that having something that has these effects would kind of kick the whole thing into a full blown experience.

So, Dextromotphan, that is what is in Cough Syrup and it is legal to buy, posses, etc. It is not any kind of drug. MXE is legal to buy and posses, but you are not allowed to take it unless you are a member of the Church of NeuroScience.

There are also plants that have these effects: Uncaria Rhynchophyllia Psychotria Colorata Huperzia Serrata

Then there is the addition option of Prolactin Inhibition, which can be done with: Zinc, Ginko Vitamin E, B6, Almonds or Almond Extract & Magnesium And possibly by anything that releases Dopamine or acts like it. So L-DOPA, THC, and a few other things maybe.

Short Wiki: People have been doing it since 2008, but it seems to be a very esoteric thing still. Not many people know about it, and it was originally started by someone who read some articles on PubMed and learned about these Enzymes, and had maybe read about this effect somewhere before going down the rabbit hole, because when he came back up (around 2008) he wrote an article that would basically get anyone tripping like they were on MDMA, at least a light version.

So I was just randomly looking for plants that naturally induce the same Serotonin receptors as Mescaline or DMT (apart from the plants that contain those, since they are illegal). I was not necessarily looking for Hallucinogenic plants, but figured it I could get the right receptors activated and smoke some weed and take an MAOI, it would probably have some pretty cool effects.

Then while making a list of plants (which was not easy, because no one else has really made a list, they just know St. John's Wort and Syrian Rue and Kanna and stuff) I accidentally found that 2008 article about Oilahuasca, then after a Google search I found an entire forum section that was dedicated to it on one website, and there were like 8 sites in total that had threads about it.

So, I added the Oilahuasca oils to my list, and added the stuff to activate them to the list. Then I saw that there were similar things (similar chemical structure and family) that had not ever been tried or even listed, so I went ahead and added those to the list as possible things that could be used. Then I compiled a bunch of threads I read by making that bottom part where it says lists of what inhibits what enzyme and what can be replaced with what.

And now I am just going to grow or order the materials and try some of the established Oilahuascas, then start doing some new ones.

Procedure, in plain English:

The pepper would be made into a tea. Solids filtered out.

Then you would get some Anise Oil, B9 or Valerian Root (of Chinese Origin, according to the forums)

So that is your Pepperidine, and you activators. Now you need your Enzyme Inhibitors. You can add L-Lysine, but it is not necessary.

Vanilla and Cinnamon work, pick one or both. You also need the Aldehyde structure from one of these.

Next. German Chamomile, Cayenne Pepper Capsules or Tangerine Skin extract/capsules

Then Almond extract, Anise Oil (if you already had it), Cinnamon, Lemon peel oil, Lime peel oil, or a cigarette or nicotine gum if you can't find anything else.

Then CBD, Echinacea Purea, Pomegranate, Pummelo, or Calamus Oil.

Then Clove oil, Catechin, Dill seed Oil or Goldenseal.

Then Kudzu or Glycerin or Caffeine

Not ALL of these things are neccisarry, but if you do 1 thing in each list, you should get VERY strong effects from whatever you take.

And according to the forums, the best thing to take is Sweet Basil Extract, in it's pure form, it is known as “Methyl Chavicol”.

Take all that other stuff like 30 minutes to an hour before the Basil Extract, and redose the B9, Anise or Valerian root to keep the effects going without taking more. According to the forums.

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