Cassiopeia Middle guide

/!\ Due to the latest patch this article is now outdated and needs a rework /!\

This is a guide for a character in League of Legends.

Cassiopeia the Serpent's Embrace.

Cassiopeia is a pure mid hero.



  • High risk High reward.
  • A sustainable burst ( :p ).
  • Pure caster. Every skill has a damage component.


  • Squishy.
  • No escape.
  • Rely on skill shot to input the maximum damage. DPS close to 0 on an initial miss.

Summoner spells

  • Flash: Will be your sole escape capability. It's mandatory on her.
  • Ignite: Ignite will deal DOT and also apply a healing/regeneration reduction about 50%.


  • Deadly Cadence (Passive): Any subsequent spell casted after the first will one cost 10% less mana up to -50%. You need to cast skills within 5 seconds to apply.

This passive is ok and further more you really need it as you will spam to do the most DPS.

  • Noxious Blast (Q): Cassiopeia fires a spell at target location dealing AOE damages per second over 3 seconds as follows: (25/38/52/65/78 +60% AP per second) then (75/115/155/195/235 +80% AP as total damages). On hit it will grant bonus movement speed to Cassiopeia for 3seconds as follows: (15/17.5/20/22.5/25% bonus MS). It applies poison on the target. Range: 850. Cooldown: 3. Cost (35/45/55/65/75 mana).

The skill shot that you can't afford to miss. It's essential to your overall DPS as we will see.

  • Miasma (W): Cassiopeia throws a poisonous puddle on the ground that will expend a bit overtime (7secs) dealing magical damage per second for 2 seconds as follows: (25/35/45/55/65 +15AP per second).Then: (225/315/405/495/585 +135% AP as maximal damages). It will also slows target(s) for 2 seconds as follows: ( 15/20/25/30/35% MS debuff). This skill applies poison to the target. Range: 850 Cooldown: 9. Cost: (70/80/90/100/110) mana.

This skill is what you have closer to an utility skill due to its slow, his pretty high cost and high cooldown. As this skill will do damages over time in its area you can almost clean a wave with it. You can throw it then roam right away.

  • Twin Fang (E): Cassiopeia throws fangs at an enemy target dealing magic damages as follows: (50/85/120/155/190 +55%AP). If the target is poisoned the cooldown is reduced to .5 seconds. Range: 700. Cooldown: 5. Cost: (50/85/120/155/190mana).

The skill locks on target. It's your main source of DPS. As you see to deal maximum damages you need to apply poison with your Q and/or W first. That’s why Cassiopeia is pretty hard to play if you miss your initial skill shot you will do nothing for 5 seconds. On the other hand if you complete your sequence perfectly you will out-Dps almost anyone. The range is close to your attack range to so you will need good positioning and mobility.

  • Petrifying Gaze (R) (Ultimate): Cassiopeia “shots” her deadly gaze in a cone in front of her dealing magic damages as follows: (200/325/450 +60% AP ). On hit if the enemies are facing Cassiopeia they are stunned for 2 seconds, if they turn their back to her they are slowed by 60% for 2 seconds. Range:850 Cooldown:(130/120/110). Cost: 100 mana.

A pretty good ulti that while require some practice. The cooldown is pretty high. It will sometimes turn fights but only with perfect timing (or if you launch it from the brush).

Skill Sequence

01 02 03 04 05 06 07 08 09 10 11 12 13 14 15 16 17 18
Q x x x x x
W x x x x x
E x x x x x
R x x x

As you have no good escape mechanism you take Q and W first. In case of an early gank you may reach the tower back successfully with those two skills. Then you max E and Q!


On The offensive tree you are looking for everything AP related. It's a standard AP build.

On the utility tree you reach runic affinity. Fleet of Foot is good to you too.


I advocate for pure damage as an AP:

  • 9X Magic penetration (marks).
  • 9X Mana regeneration per level (seals).
  • 9X Flat AP (glyphs). Some will take MR per lvl.
  • 3X Flat AP (Quintessences).


As starting items: Doran's ring (400) + 2 hps (35*2) pot are standard. An early Rod of Ages (2800) is ok it provides you what you need: more ap and mana and health. As you rely heavily on mobility a Rylai's crystal Scepter (2900) will synergize well with your kit. Cassiopeia has hit'n'run abilities but short range on E. So you have to get in and out but you will expose yourself every time. It can be pretty tricky to play her optimally. You can pair Rylai's Crystal scepter with a Liandry's Torment (2900) (And your W) Then you will do even more damages over time. If you have difficulties with CC, Zhonya's hourglass (3200) is your best friend. In a standard game you do Rabadon's Death (3300) Cap after core.

Gameplay mid

You can zoom a lot of mids with your skills. Cassiopeia relies more than everyone on good positioning. You can also push the lane fast then looking for ganks but she's not the best heroe at it. If your are caught in the river solo you are dead or you have Flash on cooldown.
When you are facing the enemy middle the usual sequence will be : Q-E-E-E. Then W if he tries to chase you when you run back. If he gets caught in it cast more E. At this point he will not try to chase you anymore. Another general tip is about the poison state. It's the same for every heroes ! So if your mates have poisoning skills you will benefit from it landing twin fangs right away! Teemo Twitch and Singed are your friends here. For the heroes that have a gap closer (Diana, Fizz) always keep your W for the moment they reach you. You will be able to run away with a W-Q combo most of the time. If you are facing some counters just clean the wave fast then roam more. Also turn the fast cast on! Fast cast enable you to cast lock-skills by pointing on target like any skill shot. With Cassiopeia's E you can't click on the target then fire. It's too slow. Also you will need fastcast on a competitive level for every hero you play.

Games | Strategy Game | Multiplayer Online Battle Arena | League of Legends

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